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Inventi Impact: Gene Medicines

Articles

  • Inventi:pgm/55/12
    ENHANCED VASCULAR ENDOTHELIAL GROWTH FACTOR GENE EXPRESSION IN ISCHAEMIC SKIN OF CRITICAL LIMB ISCHAEMIA PATIENTS
    30-Sep-2012 Research 2012 : October - December
    Silvia Bleda, Joaquin de Haro, Francisco Acin, Cesar Varela, Leticia Esparza

    Objectives. To perform a quantitative analysis of the vascular endothelial growth factor (VEGF) gene transcription in the skin of\r\nischemic legs and provide information for VEGF in the pathogenesis in critical limb ischemia (CLI). Methods. Skin biopsies were\r\nobtained from 40 patients with CLI. Control samples came from 44 patients with chronic venous disease. VEGF gene expression\r\nwas analysed using quantitative polymerase chain reaction. Results. Patients with CLI had higher skin VEGF expression than\r\ncontrol group (RQ: 1.3 �± 0.1 versus 1, P = 0.04). Conclusions. We found an association between ischemic skin and an elevated\r\nVEGF expression in legs from patients with CLI. These data support that the mechanism for VEGF upregulation in hypoxia\r\nconditions is intact and acts appropriately in the ischaemic limbs from patients with CLI.

    How to Cite this Article
    CC Compliant Citation: Silvia Bleda, Joaquín de Haro, Francisco\r\nAcin, César Varela, and Leticia Esparza, â??Enhanced Vascular\r\nEndothelial Growth Factor Gene Expression in Ischaemic Skin of\r\nCritical Limb Ischaemia Patients,â? International Journal of\r\nVascular Medicine, vol. 2012, Article ID 691528, 4 pages, 2012.\r\ndoi:10.1155/2012/691528
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